Association of the apolipoprotein E ε4 allele in a Serbian population with Alzheimer’s dementia

Although single nucleotide polymorphisms rs429358 and rs7412 in the apolipoprotein E gene (APOE) are widely investigated to analyze APOE alleles, there no data on their association with Alzheimer?s disease (AD) dementia a Serbian population. This study aimed investigate distribution of ?2/?3/?4 alleles patients due AD cognitively unimpaired subjects assess ?4 allele risk A case-control included individuals. were analyzed using Real-Time PCR method allelespecific TaqMan assays, followed by carrier status analysis. Patients had significantly higher frequency than control group (P<0.001). The was found be associated 3-fold compared reference ?3 In conclusion, this is first suggest that carriers have developing those who carry